Protein Details: Chloride channel protein ClC-Ka

Protein ID

ICDB_Pro_0766

Protein Name

Chloride channel protein ClC-Ka

Gene Name

Clcnka; Clcnk1

Organism

Rattus norvegicus (Rat)

Length

687 amino acids

AlphaFoldDB

AF-Q06393-F1-model_v4.pdb

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization; signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.

Sequence

MEELVGLREGSSGKPVTLQELWGPCPRIRRGVRRGLEWLKERLFRVGEDWHFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSWTVYPVALLSFSSGFSQSISPFSGGSGLPELKTMLSGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKVGPFVHLSVMISAYLGRVRAKTIGETENKAKEIEMLSAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWNYWRGFFAATCGAFMFRLLGVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFICGVLSCAYLFCQRTFLRFIKTNRYTSRLLATSKPSYAALVALVLASITYPPGVGRFMASRLSMAEHLHSLFDNNSWALMTRNSSPPWPAEPDPQNLWLEWCHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGREVNPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAISQNCQPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNCNLTTLAKDTPLEEVVKVVTSTEVSQYPLVETRESQTLVGIVERTHLVQALQTQPASWAPGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHSLFERLTLQSLFVTSRGKAVGSVSWAELKKAISTLINPPAPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 259; /ligand="Ca(2+)"; BINDING 261; /ligand="Ca(2+)"; BINDING 278; /ligand="Ca(2+)"; BINDING 281; /ligand="Ca(2+)";

Disease

Location

Expressed predominantly in the kidney. Expressed strongly in the cortical thick ascending limb and the distal convoluted tubule; with minor expression in the S3 segment of the proximal tubule and the cortical collecting tubule.

DOI ID

10.1016/s0021-9258(18)53545-6; 10.1016/s0021-9258(17)32293-7; 10.1073/pnas.91.15.6943; 10.1007/s00424-002-0819-8; 10.1007/s00424-003-1098-8

RefSeq

NP_445779.1